A pregnant woman lowers the allergy risk for child when eating peanuts

Allergic reactions to peanuts and tree nuts can range from mild to life-threatening. But new research suggests that pregnant women who are not allergic to the nuts/legumes and who eat more of them during pregnancy lower the risk of their child developing an allergy to the food.

Children whose mothers did not have an allergy and who consumed the highest amount of peanuts or tree nuts - which was five times a week or more - had the lowest risk of developing an allergy to the food.

However, the researchers note that this lower risk of peanut or tree nut (P/TN) allergies was not found in children whose mothers had the allergy.

Most pregnant women 'should not restrict diets'

The investigators say their study is in line with the theory that exposure to early allergens "increases the likelihood of tolerance," lowering risks of developing food allergies during childhood.
Though they say subsequent studies are needed to confirm their findings, they add that their "data support the recent decisions to rescind recommendations that all mothers avoid P/TN during pregnancy and breastfeeding."

Dr. Ruchi Gupta, agrees that women "should not restrict their diets during pregnancy." Though he warns that women who are allergic to nuts should not consume them, he acknowledges the benefits of women eating a diverse range of foods during pregnancy.

Dr. Gupta continues:
     "For now though, guidelines stand: pregnant women should not eliminate nuts from their diet as peanuts are a good source of protein and also provide folic acid, which could potentially prevent both neural tube defects and nut sensitization."

Girls who eat more peanut butter during their high school years are less likely to develop benign breast disease by the age of 30 than girls who do not.

Infection

FluMist, Fluenz (influenza virus vaccine live, intranasal)

FluMist/Fluenz (influenza vaccine live,intra-nasal) is an intra-nasal live, attenuated,trivalent influenza vaccine.

 

Merrem/Meronem (meropenem)

Merrem/Meronem (meropenem) is a carbapenem anti-bacterial used for the treatment of serious infections in hospitalised patients.
Licensed from Dainippon Sumitomo.

Synagis (palivizumab)

Synagis (palivizumab) is a humanised MAb used for the prevention of serious lower respiratory tract disease caused by respiratory syncytial virus (RSV) in paediatric patients at high risk of acquiring RSV disease.

 

Cubicin (daptomycin)

Cubicin (daptomycin) is a cyclic lipopeptide anti-bacterial used for the treatment of serious infections in hospitalised patients.
Licensed from Cubist Pharmaceuticals, Inc.

Scientists find aggressive new strain of HIV

Patients infected with new HIV strain develop AIDS over two years faster than those with other versions of the virus

An estimated 35.5 million people around the world live with HIV [EPA]

A new and more aggressive strain of HIV discovered in West Africa causes significantly faster progression to AIDS, researchers at Sweden's Lund University have found.
The strain, called A3/02, was discovered in 2011 and is part of ongoing HIV/AIDS research.
So far, it has only been identified in the West African country of Guinea-Bissau and forms when two of the most common strains in the region fuse together.

"The good news is that as far as we know the medicines that are available today are equally functional on all different subtypes of variants".  Angelica Palm,  Lund University

"Individuals who are infected with the new recombinant form develop AIDS within five years," Angelica Palm, one of the scientists involved in the study, said on Thursday.
"That's about two to two-and-a-half years faster than one of the parent [strains].
Research shows that recombinant strains, those created when different DNA combines, are a cause for concern.
"There have been some studies that indicate that whenever there is a so-called recombinant, it seems to be more competent or aggressive than the parental strains," Palm said.
There are two main types of the HIV virus: HIV-1 and HIV-2 with HIV-1 being the most common. But within those two categories, there are numerous subtypes.
The HIV virus can even mutate inside an infected person, according to the World Health Organisation.
But the scientists reassured patients that existing drugs will still effectively treat the new strain regardless of the speed at which it develops into AIDS.
"The good news is that as far as we know the medicines that are available today are equally functional on all different subtypes of variants," Palm said.

Other strains
A person goes from having HIV to AIDS when his or her white CD4 cell count, a white bloodcell that helps fight infection, drops below 200, according to the Mayo Clinic.
An estimated 35.5 million people around the world live with HIV, a virus that destroys the immune system and often leads to complications like pneumonia, tuberculosis,diarrhoea and tumours, according to the WHO.
But while the study only found the new strain in West Africa, scientists warn that other rapidly developing strains probably exist in regions like Europe and the US, where there are high levels of immigration.
"It is highly likely that there are a large number of circulating recombinants of which we know little or nothing," Patrik Medstrand, professor of clinical virology at Lund University, said.

Sources of multivitamin and selenium supplements

Vitamins are natural substances that your body needs to grow, develop, and function normally. Vitamins are contained in food; a well-balanced diet usually provides all of the vitamins required. However, there are times, such as during pregnancy, childhood and when having HIV,  your body needs more vitamins than usual . During certain illnesses, your body either cannot get or cannot efficiently use all of the vitamins it needs

Multivitamins are prescribed for patients who need extra vitamins, who cannot eat enough food to obtain the required vitamins, or who cannot receive the full benefit of the vitamins contained in the food they eat

When should this medicine be used?

Multivitamins come in regular tablets, chewable tablets, capsules, and oral liquid. They are usually taken once a day.

Apart from medicines, multivitamins are availlable from food such as,

• Spinach and lettuce - source of Vitamin A, Vitamin C, Folate and Manganese
• Avocado - Vitamin E, Vitamin C, Folate, Pantothenic Acid, Magnesium, Potassium and Copper
• Salmon - Vitamin B6, Vitamin B12, Niacin, Potassium and Selenium
• Quinoa - Vitamin B6, Folate, Phosphorus, Magnesium, Iron and Zinc
• Omega 3 Eggs - Vitamin E, Vitamin B12, Vitamin D, Folate and Selenium
• Pumpkin Seeds - Vitamin K, Iron, Magnesium and Zinc

Selenium food and pills

It normalize the mood.Selenium is claimed to be useful for treating or preventing various medical conditions, such as HIV or AIDS, heart disease, and arthritis. 

 Rich vegetarian sources of selenium are garlic, onions, tomatoes and milk.

From university of Miami research suggest that taking daily selenium supplement may block the build up of HIV in a patient's blood.

Selenium deficiencies have been recorded in HIV patients, and evidence suggests the mineral can improve the function of the immune system

More immune cells
The two groups had similar selenium levels at the beginning of the study, but after nine months levels were higher in the group taking the capsules containing the mineral.
Those with higher selenium levels in their blood were more likely to have a lower HIV viral load, and higher numbers of CD4 cells, which play a key role in fighting off infection.

 Writing in the journal, the researchers said: "Given the challenges of using conventional pharmacotherapy to achieve and maintain virologic suppression in HIV-spectrum disease, our results support the use of selenium as a simple, inexpensive and safe adjunct therapy."
Yusef Azad, director of the National Aids Trust, described the research as valuable.
"However, in interpreting this new report, it must be remembered that antiretroviral therapy is the only currently effective treatment for HIV"

Multivitamins May Help Fight HIV Progression: Study

But supplements tested only on those who hadn't started medications

TUESDAY, Nov. 26, 2013 (HealthDay News) -- New research from Africa suggests that basic multivitamin and selenium supplements might greatly lower the risk that untreated people with the AIDS virus will get sicker over a two-year period.

It's not clear how patients who take the vitamins and mineral might fare over longer periods. And the impact of the study in the United States will be limited because many Americans diagnosed with HIV, the virus that causes AIDS, immediately begin treatment with powerful medications known as anti-retroviral drugs. Those in the African study hadn't yet begun taking drugs to keep the virus at bay.

Still, "it is incredibly useful to find new strategies to delay the progression of HIV disease," said Dr. Jared Baeten, an associate professor of global health at the University of Washington in Seattle who's familiar with the findings. "Not every HIV-infected person is immediately willing, or able, to initiate anti-retroviral therapy. Inexpensive, proven treatments ahead of starting anti-retroviral therapy can fill an important role."

At issue: Do HIV-infected people benefit from nutritional supplements? Previous research has suggested that even well-fed people infected with HIV may not properly process nutrients in food, said study author Marianna Baum, a professor of dietetics and nutrition at Florida International University's Stempel School of Public Health.

The researchers wondered whether the immune system would get a boost if patients who hadn't yet begun anti-retroviral treatment took nutritional supplements. No study had looked at this before, Baum noted.

For the study, published in the Nov. 27 issue of the Journal of the American Medical Association, the researchers divided nearly 900 HIV-infected patients in the African country of Botswana into several groups. Some took a placebo, a sugar pill with no active ingredients. Others took a multivitamin including B, C and E vitamins. Another group took the multivitamin along with supplements of the mineral selenium, and still others took only selenium.

None of the treatments had a noticeable effect except the combination of multivitamin and selenium. After adjusting their statistics so they wouldn't be thrown off by various factors, the researchers reported that those who took the combination were about half as likely to show signs over two years that their infection had progressed toward AIDS as those who took the placebo.

Overall, the risk that the disease would progress over the two years of the study was fairly low: 32 of the 217 who took the placebo suffered progression of the disease, she said, compared to 17 of the 220 who took the vitamin/mineral combination.

What causes Acne?

Why people in puberty get acne?

Most people going through puberty get acne because the puberty hormones can make the glands inside their pores (those tiny holes in skin) start making too much oil. Hair follicles (where a hair grows out of your skin) get blocked by dead skin cells, and bacteria grows. The bacteria makes your skin erupt into pimples. These are usually on the face, shoulders, arms, back, and chest. They can look red, white, or black.
Guys tend to have more acne than girls do, because their skin makes more oil.

Foods to boost your brainpower

Eating well is good for your mental as well as your physical health. The brain requires nutrients just like your heart, lungs or muscles do. But which foods are particularly important to keep our grey matter happy?

1. Opt for wholegrains

Like everything else in your body, the brain cannot work without energy. The ability to concentrate and focus comes from the adequate, steady supply of energy - in the form of glucose in our blood to the brain. Achieve this by choosing wholegrains with a low-GI, which release glucose slowly into the bloodstream, keeping you mentally alert throughout the day. Opt for 'brown' cereals, wheatbran, granary bread and brown pasta.

2. Eat oily fish

Essential fatty acids (EFAs) cannot be made by the body and must be obtained through diet. The most effective omega-3 fats occur naturally in oily fish as EPA and DHA. Good sources include linseed (flaxseed) oil, soya bean oil, pumpkin seeds, walnut oil and soya beans. They are good for healthy brain function, the heart, joints and general wellbeing. Oily fish contains EPA and DHA in a ready-made form, which enables the body to use it easily. The main sources of oily fish include salmon, trout, mackerel, herring, sardines, pilchards and kippers. Low DHA levels have been linked to a higher risk of developing Alzheimer's disease and memory loss.

3. Binge on blueberries

Evidence accumulated at Tufts University in the United States suggests that the consumption of blueberries may be effective in improving or delaying short term memory loss. Widely available, so there's no excuse.

4. Eat more tomatoes

There is good evidence to suggest that lycopene, a powerful antioxidant found in tomatoes, could help protect against the kind of free radical damage to cells which occurs in the development of dementia, particularly Alzheimer's.

5. Add vitality with vitamins

Certain B vitamins - B6, B12 and folic acid - are known to reduce levels of homocysteine in the blood. Elevated levels of homocysteine are associated with increased risk of stroke, cognitive impairment and Alzheimer's disease. A study of a group of elderly patients with mild cognitive impairment found that after two years of intervention with high doses of B6, B12 and folic acid there was significantly less brain shrinkage compared to a subset given placebo treatment.

6. Get a blackcurrant boost

Vitamin C has long been thought to have the power to increase mental agility. One of the best sources of this vital vitamin are blackcurrants and oranges.

7. Pick up pumpkin seeds

Just a handful of pumpkin seeds a day is all you need to get your recommended daily amount of zinc, vital for enhancing memory and thinking skills.

8. Bet on broccoli

A great source of vitamin K, which is known to enhance cognitive function and improve brainpower.

9. Sprinkle on sage

Sage has long had a reputation for improving memory and although most studies focus on sage as an essential oil, it could be worth adding fresh sage to your diet too.

10. Go nuts

A study published in the American Journal of Epidemiology suggests that a good intake of vitamin E might help to prevent cognitive decline, particularly in the elderly. Nuts are a great source of vitamin E along with leafy green vegetables, asparagus, olives, seeds, eggs, brown rice and wholegrains.

Brainpower supplements

Although research linking diet and dementia is still in its infancy, there are a few important relationships between nutrients and brain health that are worth exploring. Having a nourishing, well rounded diet gives our brain the best chance of avoiding disease. If your diet is unbalanced for whatever reason, you may want to consider a multivitamin and mineral complex and an omega-3 fatty acid supplement to help make up a few of the essentials. If you are considering taking a supplement it is best to discuss this with a  qualified healthcare professional
 

Bee Venom Destroys HIV

Nanoparticles containing bee venom toxin melittin can destroy human immunodeficiency virus (HIV) while at the same time leaving surrounding cells unharmed, scientists from Washington University School of Medicine reported in the March 2013 issue of Antiviral Therapy.

The researchers said that their finding is a major step toward creating a vaginal gel that can prevent HIV spread. HIV is the virus that causes AIDS.

Joshua L. Hood, MD, PhD, a research instructor in medicine, said:

"Our hope is that in places where HIV is running rampant, people could use this gel as a preventive measure to stop the initial infection."

Melittin destroys some viruses and malignant tumor cells

Melittin is a powerful toxin found in bee venom. It can poke holes in the protective viral envelope that surrounds the human immunodeficiency virus, as well as other viruses. Free melittin in large-enough quantities can cause considerable damage.

Senior author, Samuel A. Wickline, MD, the J. Russell Hornsby Professor of Biomedical Sciences, has demonstrated that nanoparticles loaded with melittin have anti-cancer properties and have the capacity to kill tumor cells. Linking bee venom with anticancer therapies is not new, in 2004 Croatian scientists reported in the Journal of the Science of Food and Agriculture that honey-bee products, including venom, could well have applications in cancer treatment and prevention.

Normal cells remain intact - the scientists showed that nanoparticles loaded with melittin do not harm normal, healthy cells. Protective bumpers were added to the nanoparticles surface, so that when they come into contact with normal cells (which tend to be much larger), the nanoparticles bounce off rather than attach themselves.

Scientists have discovered a powerful toxin in bee venom that could end up playing a crucial role in preventing the spread of HIV.

Visit Washington University's website

HIV is much smaller than the nanoparticles and fits in between the bumpers. When HIV comes across a nanoparticle it goes in between the bumpers and comes into direct contact with its surface, which is coated with the bee toxin, which destroys it.

Hood explained "Melittin on the nanoparticles fuses with the viral envelope. The melittin forms little pore-like attack complexes and ruptures the envelope, stripping it off the virus."

While most anti-HIV medications work on inhibiting the virus' ability to replicate, this one attacks a vital part of its structure. The problem with attacking a pathogen's ability to replicate is that it does not stop it from starting an infection. Some HIV strains have found ways to circumvent replication-inhibiting drugs, and reproduce regardless.

Hood said:

"We are attacking an inherent physical property of HIV. Theoretically, there isn't any way for the virus to adapt to that. The virus has to have a protective coat, a double-layered membrane that covers the virus."

Melittin nanoparticles may prevent and treat existing HIV infections

Hood believes that the melittin-loaded nanoparticles have the potential for two types of therapies:

• A vaginal gel to prevent the spread of HIV infection
• Therapy for existing HIV infections, particularly drug-resistant ones

In theory, if the nanoparticles were injected into the patient's bloodstream, they should be able to clear the blood of HIV.

Hood said "The basic particle that we are using in these experiments was developed many years ago as an artificial blood product. It didn't work very well for delivering oxygen, but it circulates safely in the body and gives us a nice platform that we can adapt to fight different kinds of infections."

Melittin attacks double-layered membranes indiscriminately, making it a potential for drug therapies beyond HIV infections. The hepatitis B and C viruses, among several others, rely on the same type of protective envelope and could be targeted and destroyed by administering melittin-loaded nanoparticles.

The gel also has the potential to target sperm, the researchers explained, making it a possible contraceptive medication. The study, however, did not look at contraception.

Hood said "We also are looking at this for couples where only one of the partners has HIV, and they want to have a baby. These particles by themselves are actually very safe for sperm, for the same reason they are safe for vaginal cells."

This study was carried out in cells in a laboratory environment. However, the nanoparticles are easy to produce - enough of them could easily be supplied for future human studies.

Recent research on HIV

Over the last few years, scientists have made strides in improving HIV/AIDS treatments and prevention strategies.

Baby "functionally cured" of HIV infection - researchers from Johns Hopkins Children's Center, the University of Mississippi Medical Center and the University of Massachusetts Medical School reported that a baby who was administered antiretroviral therapy thirty hours after being born was "functionally cured"

Mega We care

  

 

DISTRIBUTION

1. Mega Way

  Is to build a
  Thinking organization which will
  Change before it is forced to and Live and Grow beyond each of us

2.Mega Value

  Respect each others differences
  Freedom in your work and personal lives
  Trust you as an adult
  Truth in what we do everyday

3. Mega Commitment

  Committed to provide Quality Products and Services to our Customers through Constant Improvement and Innovation

4. Mega Objective

  Is to create value by Marketing and Selling Medicines in Developing Countries

 

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• Children
• Diabetics
• Heart Health
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• Liver Tonic
• Mega We Care Range
• Men's Health
• Skin Care
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• Sports Supplements
• Well-Being
• Women's Health

OTC

• Analgesics & NSAIDS
• Gastrointestinal Disorders

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• Cardiology
• Dermatology
• Diabetics
• Gastroenterology
• Ortho
• Respiratory
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Production Overview

• Largest soft gelatin manufacturer in Southeast Asia.
• World class pharmaceutical facility approved by Therapeutic Goods Administration (Australia ) FDA .
• Highly Qualified Team with more then 20 years experience of Manufacturing, Formulation Development & Regulatory Affairs
• Products tested under strict CGMP
• Laboratories are equipped with sophisticated instruments such as HPLC, HPTLC, AAS,GC, Dissolution Apparatus, etc.

Product Development

• Development team has years of expertise in developing soft gels, tablets, hard-capsules, powders and in novel drug delivery systems.
• Expertise in handling water insoluble drugs & enhancing bioavailability through technologies like microemulsions, nanoemulsions and solubilization.
• Well-equipped walk-in stability chambers to conduct stability studies as per ICH guidelines
• IPR team at Mega , with sound patent intelligence , determine the strategic development of generic products.
• Wide range of analytical capabilities and pilot scale manufacturing facilities to accelerate product development

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GlaxoSmithKline - Medical manufacturers and suppliers

 

GlaxoSmithKline - one of the world's leading research-based pharmaceutical and healthcare companies - is committed to improving the quality of human life by enabling people to do more, feel better and live longer.

Our prescription of medicines  

Our prescription medicines include treatments for a wide range of conditions such as infections, depression, skin conditions, asthma, heart and circulatory disease and cancer.

The names of medicines may be different across countries. Our medicines can also be in various stages of approval around the world and may not be available in every country.
Regulations restrict the type of information that a company can provide about prescription medicines and vaccines. Therefore we do not provide medical information on this website but operate a range of sites for healthcare professionals and consumers as part of our health.gsk website, where you will find the patient information leaflets or prescribing information for our medicines.
Please note that this information is often specific to a country or region and is not intended to replace the advice of a qualified doctor.

Product information

Find more information for consumers, healthcare professionals, including how to report a side effect at health.gsk.com





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DENK PHARMA , best choice , high quality and low price

Quality for health – made in Germany motivates us because...

your health is precious

In a global world it is difficult to know where a product is manufactured. Therefore DENK PHARMA has created something unique. All DENK PHARMA products are:

• Manufactured in Germany
• Quality controlled in Germany
• Registered in Germany

DENK PHARMA was founded in Munich, Germany in 1948. We have a strong focus on export markets and presently supply our DENK PHARMA premium medicine to over 50 countries around the world. In Germany our products are sold through co-marketing agreements with other companies.
  
QUALTIY CONTROL

Discover DENK Pharma Quality control

peace of mind for prescriber and patient

• Production-integrated computer systems guide, control and document every step of the production process
• Every finished product is tested for comp6liance with relevant legal requirements (EC-GMP guidelines, Marketing Authorizations) and is released for sale by our Qualified Person
• The specifications and test methods comply with the requirements of the European Pharmacopoeia and USP
• All tablets and suppositories are subjected to dissolution tests, to ensure perfect active ingredient absorption
• Our laboratories are state-of-the-art. Over 40 HPLC units are available for analysis of the final products                                                                          

           .........................................................................................................................

Clopi-Denk 75

Benefits

• 75mg clopidogrel
• Prevention and treatment of atherothrombotic events including acute coronary syndrome and thromboembolic events in atrial fibrillation 
• Proven in mono, dual and triple therapy
• Antiplatelet inhibitor of choice in patients who do not undergo invasive strategies, but alternative medical treatment in ACS
• Once daily - good compliance

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